Finished Research
Central Institute(RIKEN CBS) (FY2014~FY2018)
Partner Institutes(FY2014~FY2018)
Clinical Research(FY2014~FY2018)
-
Identification of
disease-common neural circuit abnormalities
Tetsuo Kobayashi（Graduate School of Engineering,
Kyoto University）
-
Translation between brain
maps in primates and brain circuits in patients with neuropsychiatric disorders using
integrative neuroimaging data resources
Kiyoto Kasai（Graduate School of Medicine,
The University of Tokyo）
-
Elucidation of pathological
neural network via imaging genetics analysis for mental disorders
Norio Ozaki（Graduate School of Medicine,
Nagoya University, Department of Psychiatry&
Department of Child and Adolescent Psychiatry）
-
The research on neural
circuit of neuropsychiatric disorders – molecular mechanism and modeling
Tetsuya Suhara（Department of Functional Brain Imaging Research
National Institutes for Quantum and Radiological Science and Technology,
National Institute of Radiological Sciences）
-
Acquisition of detailed
functional and structural brain images of human healthy subjects for promotion of understanding
brain circuits of the marmoset, a new animal model for neuropsychiatric diseases
Kenji Matsumoto（Brain Science Institute,
Tamagawa University）
-
Translation
between brain maps in primates circuits in patients with neuropsychiatric disorders using
integrative neuroimaging data resources
Kiyoto Kasai（Graduate School of Medicine,
The University of Tokyo）
-
Elucidation of
pathological neural network via identification of rare genomic variants associated with mental
disorders
Norio Ozaki（Graduate School of Medicine, Nagoya University, Department of Psychiatry &
Department of Child and Adolescent Psychiatry）
-
Elucidation of
neural circuit responsible for cognition and behavior in disease pathology
Ryota Hashimoto（United Graduate School of
Child Development,
Osaka University）
-
The research on
neural circuit of neuropsychiatric disorders – molecular mechanism and modeling
Tetsuya Suhara（Department of Functional Brain Imaging Research
National Institutes for Quantum and Radiological Science and Technology,
National Institute of Radiological Sciences）
-
Investigation of
altered neural circuits in autism spectrum disorder and schizophrenia using multimodal MRI and
development of cross-species translatable measures of brain functions
Ryuichiro Hashimoto（Medical Institute of Developmental Disabilities Research,
Showa University Karasuyama Hospital
）
-
Neural pathways
for saliency detection during free-viewing
Masatoshi Yoshida（National Institute for Physiological Science, National Institutes of
Natural Sciences）
-
Elucidation of
neural networks associated with mood disorders by analyzing neuroimaging
Yasumasa Okamoto（Graduate School of Biomedical Sciences, Hiroshima University
）
-
Analysis of
molecular-motor in animal models
Yosuke Takei（University of Tsukuba）
-
Translational
research for neuronal circuitry pathologies of Parkinson’s and cerebrovascular diseases
Ryosuke Takahashi（Department of Neurology
Kyoto University Graduate School of Medicine
）
-
Identification
of mechanism for motor paralysis and higher brain dysfunction after cerebrovascular disorder，and
establishment the translatable biomarkers for their functional recovery using nonhuman primate
model
Tadashi Isa（Department of Neuroscience,
Graduate School of Medicine,
Kyoto University）
-
Elucidation
of injured neural networks and their compensatory mechanisms due to the acute and chronic
neurological disorders
Miho Murata（National Center Hospital,
National Center of Neurology and Psychiatry
）
-
Development
of PET probes to detect synaptic proteins
Takuya Takahashi（Yokohama City University,
Graduate School of Medicine）
-
The
ultrastructural identification of translatable biomarkers for the diagnosis of the early stages
of Parkinson’s disease and related disorders
Masato Koike（Juntendo University,
Graduate School of Medicine）
-
The
analysis of pathological neural networks in the patients with movement disorders and animal
disease models
Toshiki Yoshimine（Global Center for Medical Engineering and Informatics, Osaka
University）
-
Comprehensive
researches to elucidate neuro-network dysfunctions in neurodegenerative dementia
Hitoshi Okazawa（Medical Research Institute / Center for Brain Integrative Research, Tokyo
Medical and Dental University）
-
Identification of
damaged neuronal circuits in very early Alzheimer disease patients and elucidation of molecular
mechanism of tau pathology spreading
Taisuke Tomita（Graduate School of Pharmaceutical Sciences, The University of Tokyo）
-
Developing
innovative therapeutic interventions for frontotemporal lobar degeneration based on the
elucidation of neural circuit disruption
Gen Sobue（Graduate School of Medicine,
Nagoya University）
-
Multiple
molecular and radiological analysis of Parkinson’s disease pathogenesis based on patients and
animal models
Nobutaka Hattori（Juntendo University,
Graduate School of Medicine）
-
Detection of a
key neural circuit in very early stage of Alzheimer’s disease
Hiroshi Matsuda（Integrative Brain Imaging Center, National Center of Neurology and
Psychiatry）
-
Translatable
imaging and mechanistic controls of a pathological cascade in age-related neurodegenerative
conditions
Makoto Higuchi（Department of Functional Brain Imaging Research
National Institutes for Quantum and Radiological Science and Technology,
National Institute of Radiological Sciences
）
-
Molecular
mechanisms of spreading of TDP-43 pathology
Masato Hasegawa（Tokyo Metropolitan Institute of Medical Science,
Department of Dementia and Higher Brain Function
）
Technology Development(FY2014~)
-
Development of innovative photo-functional small molecule probes for advancing comprehensive
understanding of brain structure and function
Yasuteru Urano（Graduate School of Pharmaceutical Sciences,
The University of Tokyo）
-
Two-photon multi-color imaging of memory circuits in the fixed and transparent brain
Haruo Kasai（Graduate School of Medicine,
The University of Tokyo）
-
Developing new imaging techniques which visualize the functional map of the brain
Junichi Nakai（Graduate School of Science and Engineering,
Saitama University）
-
Development of technologies for pathway-specific manipulation and structural analysis of neural
circuits aiming at functional brain research of common marmosets
Kazuto Kobayashi（Institute of Biomedical Sciences,
Fukushima Medical University）
-
Development of innovative method for projection pathway specific gene expression to manipulate
neural network
Akihiro Yamanaka（Research Institute of Environmental Medicine,
Nagoya University）
-
Developing basic technologies toward comprehensive circuit mapping of the primate brain
Hiroki R. Ueda（Graduate School of Medicine,
The University of Tokyo）
-
Multidisciplinary analyses of neuronal circuits and structures to understand marmoset brain
functions
Atsushi Nambu（National Institute for Physiological Sciences）
-
Comprehensive measurement and analysis of spatiotemporal transcriptome and epigenome dynamics in
the common marmoset brain
Yasuhiro Go（Center for Novel Science Initiatives,
National Institutes of Natural Sciences）
-
Developing cell type-specific gene expression techniques in marmoset brain
Hirokazu Hirai（Graduate School of Medicine,
Gunma University）
-
Bridging the gap between macroscopic and microscopic functional organization with multimodal
functional mapping
Kenichi Ohki（Graduate School of Medicine,
The University of Tokyo）
-
Development of super-resolution multi-photon microscopy by utilizing a novel semiconductor based
light source
Tomomi Nemoto（Research Institute for Electronic Science,
Hokkaido University）
-
Fast 3D recording of neuronal activity and long-term imaging of activity traces through
development of innovative probing technologies
Haruhiko Bito（Graduate School of Medicine,
The University of Tokyo）
-
Development of optical techniques to manipulate and measure cortical circuits with higher brain
functions
Masanori Matsuzaki（Graduate School of Medicine,
The University of Tokyo）
-
Development of the marmoset embryo-manipulating technologies for efficient generation of
knock-in animals and reduction of generation interval
Atsu Aiba（Graduate School of Medicine,
The University of Tokyo）
-
Computational frameworks for multi-scale models using structural and functional brain map data
Kenji Doya（Neural Computation Unit,
Okinawa Institute of Science and Technology Graduate University）
-
A novel multi-neuronal recording with optogenetic identification of axonal projections
Yoshikazu Isomura（Brain Science Institute,
Tamagawa University）
-
Ultra-thin Electronic Sensor System for Marmoset’s Brain Signal measurement
Tsuyoshi Sekitani（The Institute of Scientific and Industrial Research,
Osaka University）
Technology Development(FY2017~)
-
Development of a method for high speed and high resolution whole-brain imaging in primates
Hitoshi Hashimoto（Graduate School of Pharmaceutical Sciences,
Osaka University）
-
Super-multicolor labeling for automatic reconstruction of neuronal circuits
Takeshi Imai（Graduate School of Medical Sciences,
Kyushu University）
-
Development of 3D imaging and analysis pipeline for marmoset brain
Hiroki Ueda（Graduate School of Medicine,
The University of Tokyo）
-
Development of innovative wide-view mapping of synaptic ensemble in the psychiatric model
Akiko Hayashi-Takagi（RIKEN Center for Brain Science）
-
Development of innovative method for an all-optical electrophysiology to measure and manipulate
neural activity
Masayuki Sakamoto（Graduate School of Biostudies,
Kyoto University）
-
Development of neural circuit tracing for mapping the connectome in the common marmoset
Fumitaka Osakada（Graduate School of Pharmaceutical Sciences,
Nagoya University）
-
Zoom-in to the ultrastructure level from the whole brain level using a tissue-clearing method as
the cornerstone
Hiroyuki Hioki（School of Medicine,
Juntendo University）
-
Production of knockout marmoset using spermatogenic cells
Takashi Shinohara（Graduate School of Medicine,
Kyoto University）
-
Mapping the structure and function of the cortico-basal ganglia network in marmosets by use of
pathway-specific labeling and manipulation technology
Kazuto Kobayashi（School of Medicine,
Fukushima Medical University）
-
AAV vector-mediated cell type-specific gene knock-down / knock-out in marmoset CNS in vivo
Hirokazu Hirai（Graduate School of Medicine,
Gunma University）
-
Analyze structures and functions of marmoset brains by multi-scale and multi-modal approaches
Atsushi Nambu（National Institute for Physiological Sciences,
National Institutes of Natural Sciences）
-
Multimodal multi-scale functional mapping of marmoset brain and development of functional
mapping at ultra-fine scale
Kenichi Ohki（Graduate School of Medicine,
The University of Tokyo）
Technology Development(FY2019~)
