Identification of damaged neuronal circuits in very early Alzheimer disease patients and elucidation of molecular mechanism of tau pathology spreading

We will clarify the pathological changes in neuronal circuits caused by genetic risk factors for Alzheimer disease (AD) and molecular mechanisms of tau pathology spreading using model mouse. In addition，we will identify the damaged neuronal circuits in brains of MCI due to AD/preclinical AD, and compare with those in mouse and common marmoset models. Final aim of our research is identification of key neuronal circuit that is damaged in very early AD brains.