第3回 Computational Neurology Club
開催日
2023年7月28日(金)9:30-11:00
開催場所
詳細
◆◆◆ 第3回『Computational Neurology Club』開催のご案内 ◆◆◆
臨床研究家としてデータサイエンスを駆使しててんかん研究を行っている、Catherine Chuさんに京大学とzoomのハイブリッドでの講演をしていただく予定です。
講演者:Catherina Chu(ハーバード大学)
開催場所:ハイブリッド(zoom+京都大学)
日時:2023年7月28日(金)9:30-11:00
タイトル:Sleep spindles: a mechanistic biomarker for cognitive dysfunction in encephalopathy
概要:In epileptic encephalopathies, epileptic activity contributes to progressive cognitive dysfunction, but the mechanism is not well understood. Several epileptic encephalopathies share the trait of pathological spike-wave activation during non-rapid eye movement sleep (EE-SWAS), a state normally dominated by physiological sleep spindles, sleep oscillations known to coordinate offline memory consolidation. We find that sleep spindles predict IQ and sleep dependent memory in epilepsy, are disrupted by epileptic spikes that propagate to the thalamus, and can be increased by both pharmacologic interventions and non-invasive stimulation. Better understanding the circuits that support and disrupt these physiological and pathological oscillations will open opportunities to address cognitive symptoms in epilepsy and other neurologic and psychiatric disorders.
Related papers:
https://www.biorxiv.org/content/10.1101/2023.04.17.537191v1
https://www.biorxiv.org/content/10.1101/2023.04.22.537937v1
お問い合わせ先
参加登録等の詳細は下記WEBページよりご確認ください。
https://boatneck-weeder-7b7.notion.site/Computational-Neurology-a945537f7cb54db3b20fa9c4e65c1e72