Multiple scale functional mapping of neuronal dynamics

Neurons receive thousands of synaptic inputs at various timings in the order of milliseconds, and convert, amplify and integrate them as chemical signals in the order of seconds to minutes, to process complex input information and maintain them as long-term memory. In this project, we develop a technique that can map intracellular signals at multiple spatiotemporal scales in live animals. For this purpose, we will develop new highly sensitive multicolor probes that can detect cellular and molecular signals in neurons, and develop new microscopy that can visualize neural signaling dynamics at multiple spatiotemporal scales simultaneously.