Acoustic-optical technologies for investigating deep brain area

To guide light to deep tissue sites in the brain, we create optical fiber or waveguide-like refractive index profiles inside brain tissues in a non-invasive manner. We will use spatiotemporal control of refractive index profiles of brain tissues by the pressure fields of nonlinear acoustic waves. We will develop novel acoustic-optical techniques based on optical and acoustical engineering technologies that enhance the performance of conventional optical stimulation and measurement methods such as optogenetics, fluorescence imaging, near-infrared spectroscopy, and whole-brain analysis with transparent brains.