Studies on neural circuit and molecular pathology based on human genome mutations in psychiatric disorders

We will combine behavior, morphology and dynamics of neural circuits, synaptic plasticity, and intracellular signaling analyses in psychiatric disorder model mice to elucidate the molecular and circuit pathology. Neurons and organoids derived from iPS cells established from patients with 22q11.2 deletion and tuberous sclerosis will also be characterized. The screening and verification of new mutation candidates involved in cross-disease episodes among schizophrenia, bipolar disorder, and autism spectrum disorder will be continued for additional elucidation of molecular and circuit pathology. The obtained information can be applied to the analysis of neural circuits and their functions in marmosets.