Understanding the mechanism of Aβ-induced aggregated tau propagation and neurocircuit degeneration in Alzheimer's disease

We will clarify the pathological relationship between amyloid-β (Aβ) deposition, the earliest pathological changes in Alzheimer disease (AD), and propagation of aggregated tau that causes the neurodegeneration. We will also elucidate the earliest damaged neurocircuit in the pathological process of AD using patient samples and disease models. Our research will highlight the key neuronal circuit that is damaged by Aβ-induced aggregated tau propagation and lead to an understanding of the conversion process from preclinical stage to AD.