Study for impairment of predictive function in psychiatric disorders using a bi-directional translational approach

This research intends to conduct a cross-disease investigation for impairment of the predictive function in psychiatric disorders using a bi-directional translational approach (Patient – Human – Non-human primate – Mouse). We intend to find the translatable phenotypes for prefrontal cortex-dependent auditory predictive function and condition predictive function. We will expand the large-scale database of the multi-center magnetic resonance imaging study in Japan and measure for people with affective disorders and autism spectrum disorder. We will find the shared and disease-specific alterations of the phenotypes and the neural and molecular basis of the impairment of the predictive function in psychiatric disorders.